[巨噬细胞移动抑制因子在胰腺癌组织中的表达]
[Expression of macrophage migration inhibition factor in pancreatic carcinoma tissue].
作者信息
Jin Zhi-qing, Zhi Fa-chao, Chen Xue-qing, Wang Ya-dong
机构信息
Institute for Digestive Disease of PLA, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
出版信息
Di Yi Jun Yi Da Xue Xue Bao. 2004 Nov;24(11):1301-3.
OBJECTIVE
To observe the expression of macrophage migration inhibitory factor (MIF) in pancreatic carcinoma tissue and analyze the relationship between MIF expression and clinical manifestations.
METHODS
MIF expression in pancreatic carcinoma and normal pancreatic tissue were detected with immunohistochemical method.
RESULT
The positivity rates of MIF in pancreatic carcinoma and normal pancreatic tissue were 69.4% (25/36) and 0 (0/10) respectively. MIF expression was found to relate to the degree of cell differentiation of pancreatic carcinoma, but not to the clinical stages or the status of lymph node metastasis.
CONCLUSION
MIF might be related to the pathogenesis of pancreatic carcinoma.
目的
观察巨噬细胞移动抑制因子（MIF）在胰腺癌组织中的表达，分析MIF表达与临床表现之间的关系。
方法
采用免疫组织化学方法检测胰腺癌组织及正常胰腺组织中MIF的表达。
结果
胰腺癌组织和正常胰腺组织中MIF的阳性率分别为69.4%（25/36）和0（0/10）。发现MIF表达与胰腺癌的细胞分化程度有关，而与临床分期或淋巴结转移状况无关。
结论
MIF可能与胰腺癌的发病机制有关。
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