Cui Yazhou, Zhang Denglu, Jia Qing, Li Tianliang, Zhang Weidong, Han Jinxiang
Shandong Medicinal Biotechnology Center, Shandong Academy of Medical Sciences, Key Laboratory for Biotech-Drugs Ministry of Health, Key Laboratory for Modern Medicine and Technology of Shandong Province, Jinan, China.
Cancer Invest. 2009 Aug;27(7):747-55. doi: 10.1080/07357900802672746.
We identified a group of hypoxia-regulated proteins upregulated in microdissected pancreatic cancer nests compared with normal pancreatic ducts. Immunohistochemical study further validated that pancreatic cancers had significantly higher expression levels of glucose-regulated protein 78, macrophage migration inhibitory factor and annexin A5 than normal pancreas tissues, these protein biomarkers also demonstrated high receiver operating characteristic curves in discriminating pancreatic cancers from normal pancreas. In conclusion, our study indicated a link between pancreatic cancer and hypoxia-regulated proteins. Glucose-regulated protein 78, macrophage migration inhibitory factor and annexin A5 might be promising targets for pancreatic cancer diagnosis and therapy.
我们鉴定出一组在显微切割的胰腺癌巢中相较于正常胰管上调的缺氧调节蛋白。免疫组织化学研究进一步证实，与正常胰腺组织相比，胰腺癌中葡萄糖调节蛋白78、巨噬细胞迁移抑制因子和膜联蛋白A5的表达水平显著更高，这些蛋白质生物标志物在区分胰腺癌与正常胰腺时也显示出高受试者工作特征曲线。总之，我们的研究表明胰腺癌与缺氧调节蛋白之间存在联系。葡萄糖调节蛋白78、巨噬细胞迁移抑制因子和膜联蛋白A5可能是胰腺癌诊断和治疗的有前景的靶点。
