Sagesaka Toshiaki
Department of Obstetrics and Gynecology, Kanamachi Central Hospital, Tokyo, Japan.
Clin Hemorheol Microcirc. 2004;31(4):243-9.
Influence of the change of red blood cell (RBC) concentration on the initiation time of blood coagulation was investigated with a damped oscillation rheometer. The blood samples from 40 volunteers were examined. After centrifuging some portion of each blood sample, an appropriate volume was taken from the lower RBC layer to add it to the autologous blood, making an artificially concentrated blood. Initiation time of coagulation of each sample from 20 males and 20 non-pregnant females was shortened according to the increase of the RBC concentration, producing a significant difference at the boundary of 5.0x10(6)/mm3 (p<0.01). The results suggest that RBC concentration may play an important role in accelerating the initial coagulation reaction of blood and that hemoconcentration could be a risk factor for thrombosis even within the normal range, especially beyond the boundary of 5.0x10(6)/mm3 of RBCs.
使用阻尼振荡流变仪研究了红细胞（RBC）浓度变化对血液凝固起始时间的影响。对40名志愿者的血样进行了检测。在对每个血样的一部分进行离心后，从较低的RBC层中取出适当体积并添加到自体血液中，制成人工浓缩血液。20名男性和20名未怀孕女性的每个样本的凝血起始时间随着RBC浓度的增加而缩短，在5.0x10(6)/mm3的边界处产生显著差异（p<0.01）。结果表明，RBC浓度可能在加速血液的初始凝血反应中起重要作用，并且血液浓缩即使在正常范围内也可能是血栓形成的危险因素，尤其是超过5.0x10(6)/mm3的RBC边界时。
