Futrakul Narisa, Panichakul Tasanee, Butthep Punnee, Futrakul Prasit, Jetanalin Pim, Patumraj Suthiluk, Siriviriyakul Prasong
Department of Physiology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Clin Hemorheol Microcirc. 2004;31(4):267-72.
A persistent proteinuria is commonly observed in nephrotic patient with focal segmental glomerulosclerosis (FSGS) under treatment with prednisolone+/-cyclophosphamide or with vasodilators (ACEI+AII receptor antagonist, calcium channel blocker and antiplatelet agent). Fourteen such patients with persistent proteinuria were subject to be treated with Ganoderma lucidum. Initial study revealed an enhanced endothelial cell cytotoxicity induced by patient's serum, and an altered immunocirculatory balance with predominant proinflammatory cytokine TNF alpha activity in the presence of defective anti-inflammatory cytokine interleukin-10. Treatment with Ganoderma lucidum suppressed endothelial cell cytotoxicity, restored immunocirculatory balance and successfully suppressed proteinuria in all of these 14 patients.
在接受泼尼松龙±环磷酰胺或血管扩张剂（血管紧张素转换酶抑制剂+血管紧张素II受体拮抗剂、钙通道阻滞剂和抗血小板药物）治疗的局灶节段性肾小球硬化（FSGS）肾病患者中，持续蛋白尿很常见。14例有持续蛋白尿的此类患者接受了灵芝治疗。初步研究显示，患者血清诱导的内皮细胞细胞毒性增强，在抗炎细胞因子白细胞介素-10缺陷的情况下，免疫循环平衡改变，促炎细胞因子肿瘤坏死因子α活性占主导。灵芝治疗抑制了内皮细胞细胞毒性，恢复了免疫循环平衡，并成功抑制了所有这14例患者的蛋白尿。
