Castelo-Branco A, Frydman N, Kadoch J, Le Du A, Fernandez H, Fanchin R, Frydman R
Service de Gynécologie-Obstétrique de Médecine de la Reproduction, France.
J Gynecol Obstet Biol Reprod (Paris). 2004 Oct;33(6 Pt 1):518-24. doi: 10.1016/s0368-2315(04)96565-9.
To evaluate the efficacy of semi natural cycle as option of treatment for the patients who have a poor prognosis to controlled ovarian hyperstimulation (COH).
Prospective study. Sixty-six patients with an ovulatory cycle who presented either altered ovarian status (AOS) or implantation failure (IMF) and had carried out a total of 133 semi natural IVF cycles were included. Once follicular dominance was established, the growth of this follicule was controlled by administration of the GnRH antagonist with exogenous gonadotrophins.
Groups AOS (n = 47) and IMF (n = 19) were similar with regard to oocyte pickup rate (81.2% and 81.1%), the oocyte recovery rate (61.4% and 64.8%) and clinical pregnancies per oocyte pickups rate (15.4% and 16.6%), respectively.
The semi natural cycle appears as option of treatment for patients who have a poor prognosis for successful in vitro fertilization.
评估半自然周期作为控制性卵巢刺激（COH）预后不良患者的一种治疗选择的疗效。
前瞻性研究。纳入66例有排卵周期、出现卵巢状态改变（AOS）或种植失败（IMF）且共进行了133个半自然体外受精周期的患者。一旦确定卵泡优势，通过给予GnRH拮抗剂和外源性促性腺激素来控制该卵泡的生长。
AOS组（n = 47）和IMF组（n = 19）在取卵率（分别为81.2%和81.1%）、卵母细胞回收率（分别为61.4%和64.8%）以及每取卵周期临床妊娠率（分别为15.4%和16.6%）方面相似。
半自然周期似乎是体外受精成功预后不良患者的一种治疗选择。
