Beddow James E, Davies Stephen G, Smith Andrew D, Russell Angela J
Department of Organic Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK.
Chem Commun (Camb). 2004 Dec 7(23):2778-9. doi: 10.1039/b410938d. Epub 2004 Oct 22.
Conjugate addition of lithium amides to (S)-N-acryloyl- or (S)-N-2'-alkylacryloyloxazolidinones and alkylation or protonation of the resulting enolates with 2-pyridone respectively provides a highly stereoselective and product complementary route to a range of (R)- and (S)-2-alkyl-3-aminopropionic acids in good yield and in high ee.
将锂酰胺与(S)-N-丙烯酰基-或(S)-N-2'-烷基丙烯酰基恶唑烷酮进行共轭加成，然后分别用2-吡啶酮对所得烯醇盐进行烷基化或质子化，可提供一条高立体选择性且产物互补的路线，以良好的产率和高对映体过量得到一系列(R)-和(S)-2-烷基-3-氨基丙酸。
