Kawada Norikazu, Miyazaki Masao, Matsuyama Mahito, Murai Katsumasa, Nakatani Ken
Department of Neurology, Yamada Red Cross Hospital.
Rinsho Shinkeigaku. 2004 Oct;44(10):703-6.
We compared vocalization and speech of 20 patients with Parkinson's disease with those of 24 healthy volunteers using acoustic analysis. The time from the beginning of pronunciation of "a" to the maximum amplitude was significantly longer in the Parkinson group than in the healthy group. In a reading aloud test using a short sentence "o-te-ra-ni-o-ba-ke-ga-de-ta (a ghost appeared in a temple)", the coefficient of variation of the mean fundamental frequency for each syllable was significantly smaller in the Parkinson group. In addition, the Parkinson group showed few changes in the fundamental frequency of the each syllable through the whole sentence, which was spoken in a monopitch pattern. However, there were no differences between the Parkinson group and the healthy volunteers in the time that each syllable was sustained and in the length of syllables. These results suggest that patients with Parkinson's disease have bradykinetic utterance. In reading aloud the short sentence, the tone of each syllable was flat and the speech was monopitch lack articulation. The saccadic eye movements of 15 of the patients with Parkinson's disease were recorded using an electrooculogram in order to evaluate the correlation with bradykinetic utterances. Although monopitch speech and bradykinetic utterances were correlated, the bradykinetic saccadic eye movements and bradykinetic utterances were not correlated.
我们使用声学分析比较了20名帕金森病患者与24名健康志愿者的发声和言语情况。帕金森病组从发“啊”音开始到最大振幅的时间显著长于健康组。在使用短句“お寺にお化けが出た（寺庙里出现了一个鬼）”的朗读测试中，帕金森病组每个音节平均基频的变异系数显著更小。此外，帕金森病组在以单音调模式说出整个句子时，每个音节的基频几乎没有变化。然而，帕金森病组与健康志愿者在每个音节的持续时间和音节长度方面没有差异。这些结果表明帕金森病患者存在运动迟缓性发声。在朗读短句时，每个音节的语调平淡，言语呈单音调且缺乏清晰度。为了评估与运动迟缓性发声的相关性，使用眼电图记录了15名帕金森病患者的扫视眼动。虽然单音调言语与运动迟缓性发声相关，但运动迟缓性扫视眼动与运动迟缓性发声不相关。
