Roberts Kade D, Lambert John N, Ede Nicholas J, Bray Andrew M
School of Chemistry, The University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia.
J Pept Sci. 2004 Nov;10(11):659-65. doi: 10.1002/psc.575.
A new method for the synthesis of cyclic head-to-side chain peptide libraries has been developed in which the key cyclization step involves reaction between a C-terminal ketone and an N-terminal hydroxylamine to form a macrocyclic oxime. This methodology efficiently delivers cyclic products that consist of mixtures of syn and anti isomers.
一种用于合成环状头对侧链肽库的新方法已被开发出来，其中关键的环化步骤涉及C端酮与N端羟胺之间的反应以形成大环肟。该方法能有效地提供由顺式和反式异构体混合物组成的环状产物。
