具有一氧化氮产生抑制活性的来自日本常山的喹诺酮生物碱。
Quinolone alkaloids with nitric oxide production inhibitory activity from Orixa japonica.
作者信息
Ito Chihiro, Itoigawa Masataka, Furukawa Akiko, Hirano Takashi, Murata Tomiyasu, Kaneda Norio, Hisada Youichi, Okuda Kazuyo, Furukawa Hiroshi
机构信息
Department of Medicinal Chemistry, Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468-8503, Japan.
出版信息
J Nat Prod. 2004 Nov;67(11):1800-3. doi: 10.1021/np0401462.
PMID:15568765
Abstract
Four new quinolone alkaloids, orixalone A (1), B (2), C (3), and D (4), together with 12 known compounds were isolated from the stems of Orixa japonica. Orixalone A (1) inhibited nitric oxide production in murine macrophage-like RAW 264.7 cells stimulated with interferon-gamma and lipopolysaccharide.
摘要
从日本常山的茎中分离出四种新的喹诺酮生物碱，常山酮A（1）、B（2）、C（3）和D（4），以及12种已知化合物。常山酮A（1）可抑制经γ-干扰素和脂多糖刺激的小鼠巨噬细胞样RAW 264.7细胞中一氧化氮的产生。
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