蕈样肉芽肿消退斑块中的粟丘疹：是否由外用氮芥诱发？
Milia in regressing plaques of mycosis fungoides: provoked by topical nitrogen mustard or not?
作者信息
Kalayciyan Aylin, Oguz Oya, Demirkesen Cuyan, Serdaroglu Server, Kotogyan Agop
机构信息
Department of Dermatology, University of Istanbul, Istanbul, Turkey.
出版信息
Int J Dermatol. 2004 Dec;43(12):953-6. doi: 10.1111/j.1365-4632.2004.01944.x.
OBJECTIVE
To report three cases of mycosis fungoides with milia formation in the regressing lesions.
PATIENTS AND SETTING
Dermatology clinic of a university hospital (referral center). Three patients with mycosis fungoides with body surface involvement of 10% in one case (stage IIb) and exceeding 30% in two cases (stages IIb and III). All patients were treated with photochemotherapy and topical nitrogen mustard ointment in a concentration of 0.01%. After approximately 3 months multiple milia erupted on regressing plaques.
RESULTS
The presence of milia was evident and was confirmed by histopathology. Regression of mycosis fungoides was noted in these plaques both clinically and in comparison with the pretreatment histologic appearance. Two of the patients showed a histological picture of follicular mucinosis.
CONCLUSIONS
We do not know the significance of milia in mycosis fungoides (MF). However, we suggest that follicular rupture or a degenerative process might result in milia formation.
目的
报告3例蕈样肉芽肿消退期皮损出现粟丘疹的病例。
患者与背景
一所大学医院（转诊中心）的皮肤科门诊。3例蕈样肉芽肿患者，1例体表受累面积为10%（IIb期），2例超过30%（IIb期和III期）。所有患者均接受光化学疗法及0.01%浓度的外用氮芥软膏治疗。大约3个月后，在消退的斑块上出现多发粟丘疹。
结果
粟丘疹的存在明显，并经组织病理学证实。这些斑块在临床上及与治疗前组织学表现比较时，均可见蕈样肉芽肿消退。2例患者表现为毛囊黏蛋白病的组织学图像。
结论
我们尚不清楚粟丘疹在蕈样肉芽肿（MF）中的意义。然而，我们认为毛囊破裂或退变过程可能导致粟丘疹形成。
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