Drew B, Leeuwenburgh C
Biochemistry of Aging Laboratory, University of Florida, Gainesville, FL 32611, USA.
Acta Physiol Scand. 2004 Dec;182(4):333-41. doi: 10.1111/j.1365-201X.2004.01371.x.
The rapid growing population of elderly illustrates the importance of understanding the mechanisms responsible for ageing and the detrimental effects on health associated with increasing age. One of the primary mechanisms may be because of the accumulation of mtDNA damage and oxidative damage with age. Previous studies have examined this correlation in post-mitotic tissues such as skeletal muscle, heart and brain with decreased mitochondrial function, such as enzymatic activities of the electron transport chain and ATP production. However, regional differences in the subcellular location of mitochondria exist and most studies have failed to differentiate the effects of these two autonomous fractions, the subsarcolemmal and intermyofibrillar populations. Hence, while future research attempts to explain the mechanisms responsible for ageing in the mitochondrion, it should also take into account the independent pathways of these two distinctly different populations.
老年人口的迅速增长凸显了理解衰老机制以及衰老对健康的有害影响的重要性。主要机制之一可能是随着年龄增长线粒体DNA损伤和氧化损伤的积累。先前的研究已在有丝分裂后组织（如骨骼肌、心脏和大脑）中研究了这种相关性，这些组织中线粒体功能下降，如电子传递链的酶活性和ATP生成。然而，线粒体亚细胞定位存在区域差异，且大多数研究未能区分这两个自主部分（肌膜下和肌原纤维间群体）的影响。因此，在未来研究试图解释线粒体衰老机制时，也应考虑这两个截然不同群体的独立途径。
