Kobayashi Hanako, Lin P Charles
Department of Radiation Oncology, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Front Biosci. 2005 Jan 1;10:666-74. doi: 10.2741/1561.
Mounting evidence demonstrates that the formation of new blood vessels, termed angiogenesis, plays critical roles in human disease development and progression. Based on these findings, there has been a tremendous effort to investigate the molecular mechanisms that drive blood vessel growth in adult tissues. Compared to physiological angiogenesis, inflammation is often accompanied with pathological angiogenesis and often is the underlying causes of many diseases such as cancer, arthritis, atherosclerosis, and others. Inflammation induces angiogenesis and reciprocally, angiogenesis facilitate inflammation. A study of the interaction between angiogenesis and inflammation will enhance our understanding of the mechanisms of diseases. It may generate novel approaches for therapy. Tie2 was recently identified as a receptor tyrosine kinase expressed principally on vascular endothelium, making it an attractive molecular target for angiogenic therapy. This review discusses the regulation of Tie2 and its angiopoietin ligand family in inflammation-associated angiogenesis focusing on cancer, arthritis, and atherosclerosis. The complexity of angiogenesis and context-dependent regulation of angiopoietin/Tie2 signaling in angiogenesis requires further studies.
越来越多的证据表明，新血管的形成，即血管生成，在人类疾病的发展和进程中起着关键作用。基于这些发现，人们付出了巨大努力来研究驱动成体组织血管生长的分子机制。与生理性血管生成相比，炎症常伴有病理性血管生成，且往往是许多疾病如癌症、关节炎、动脉粥样硬化等的潜在病因。炎症诱导血管生成，反之，血管生成促进炎症。对血管生成与炎症之间相互作用的研究将增进我们对疾病机制的理解。这可能会产生新的治疗方法。Tie2最近被鉴定为主要在血管内皮细胞上表达的受体酪氨酸激酶，使其成为血管生成治疗的一个有吸引力的分子靶点。本综述讨论了Tie2及其血管生成素配体家族在与炎症相关的血管生成中的调节作用，重点关注癌症、关节炎和动脉粥样硬化。血管生成的复杂性以及血管生成素/Tie2信号在血管生成中的背景依赖性调节需要进一步研究。
