[注意力缺陷多动障碍与酒精依赖：共同的遗传易感性？]
[ADHD and alcohol dependence: a common genetic predisposition?].
作者信息
Wodarz Norbert, Lange Kirsten, Laufkötter Rainer, Johann Monika
机构信息
Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität am Bezirksklinikum Regensburg.
出版信息
Psychiatr Prax. 2004 Nov;31 Suppl 1:S111-3. doi: 10.1055/s-2004-828449.
INTRODUCTION
Nearly 50 % of subjects with continuing symptoms of attention-deficit hyperactivity disorder (ADHD) in adulthood show a comorbid substance use disorder. Both, ADHD and alcohol dependence have a high genetic load and might even share overlapping sources of genetic liability.
METHOD
We investigated phenotype and 5-HTT/5-HT2c allelic characteristics in 314 alcoholics of German descent.
RESULT
21 % of the alcoholics fulfilled DSM-IV-criteria of ADHD with ongoing symptoms in adulthood. There was no significant difference in 5-HTT- or 5-HT2c-allele distribution between alcoholics and matched controls or between alcoholics with or without ADHD.
CONCLUSION
In our sample the functional relevant 5-HTT-promoter and the 5-HT2c-receptor Cys23Ser polymorphism do not contribute to the supposed common genetic predisposition of ADHD and alcohol dependence.
引言
成年期仍有注意力缺陷多动障碍（ADHD）持续症状的患者中，近50%表现出共病物质使用障碍。ADHD和酒精依赖都具有较高的遗传负荷，甚至可能共享重叠的遗传易感性来源。
方法
我们调查了314名德国血统酗酒者的表型和5-羟色胺转运体（5-HTT）/5-羟色胺2C受体（5-HT2c）等位基因特征。
结果
21%的酗酒者符合ADHD的《精神疾病诊断与统计手册》第四版（DSM-IV）标准，成年期仍有症状。酗酒者与匹配对照组之间，以及有或无ADHD的酗酒者之间，5-HTT或5-HT2c等位基因分布无显著差异。
结论
在我们的样本中，功能相关的5-HTT启动子和5-HT2c受体Cys23Ser多态性对ADHD和酒精依赖假定的共同遗传易感性无影响。
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