Messer Thomas
Bezirkskrankenhaus Augsburg.
Psychiatr Prax. 2004 Nov;31 Suppl 1:S161-3. doi: 10.1055/s-2004-828473.
Although there were multiple initiatives to modify course and outcome of schizophrenia by optimizing present psychopharmacologic strategies many unsolved problems still exist. There is no doubt that first generation antipsychotics reduce positive symptoms of psychosis but the impact on negative symptoms or disturbances of affect or cognition remains very poor. In contrast second generation antipsychotics show significantly a better tolerability, especially less extrapyramidal side effects. However, they may initiate strong individual side effects. This article reflects advantages and disadvantages of modern antipsychotics on the course of schizophrenia.
尽管有多项举措试图通过优化当前的精神药理学策略来改变精神分裂症的病程和结局，但仍存在许多未解决的问题。毫无疑问，第一代抗精神病药物可减轻精神病的阳性症状，但对阴性症状或情感或认知障碍的影响仍然很差。相比之下，第二代抗精神病药物显示出明显更好的耐受性，尤其是较少的锥体外系副作用。然而，它们可能引发强烈的个体副作用。本文反映了现代抗精神病药物在精神分裂症病程中的优缺点。
