Finzel Martin, Fric Mirijam, Laux Gerd
Bezirksklinikum Gabersee.
Psychiatr Prax. 2004 Nov;31 Suppl 1:S178-80. doi: 10.1055/s-2004-828465.
The introduction of Ziprasidone stimulated discussion about frequency and importance of QTc-interval prolongations with antipsychotic therapy. In an open non-randomized study we collected data about QTc-interval, electrolytes, vital parameters and associated clinical symptoms in patients treated with atypical antipsychotics. 33 patients were scanned and some moderate QTc-interval prolongations but no clinical events were seen. Due to scarcity of such events existing data should be completed by large scale clinical studies and by registration of severe QTc-interval prolongations and torsades de pointes in central drug monitoring systems.
齐拉西酮的引入引发了关于抗精神病药物治疗导致QTc间期延长的频率和重要性的讨论。在一项开放性非随机研究中，我们收集了接受非典型抗精神病药物治疗患者的QTc间期、电解质、生命体征参数及相关临床症状的数据。对33例患者进行了扫描，发现了一些中度QTc间期延长，但未观察到临床事件。由于此类事件较少，现有数据应由大规模临床研究以及在中央药物监测系统中记录严重QTc间期延长和尖端扭转型室速来补充完善。
