Matsuoka Hitoshi, Mizushima Yuki, Kawano Masako, Tachibana Naoko, Sawada Yoshiko, Kato Sachiko, Nagakura Hiromi, Tanaka Miyuki, Suzuki Keiko, Tadanobu Kuribayashi
Dept of Internal Medicine, Koga General Hospital.
Gan To Kagaku Ryoho. 2004 Nov;31(12):2017-20.
The stomatitis accompanying chemotherapy reduces a patient's QOL. Many reports have suggested that some kinds of gargling agents for oral mucositis shorten the duration and severity of symptoms. This study tested the prevention and efficacy against stomatitis of a herbal medicine (Syousaikotou) as a gargling agent for patients receiving chemotherapy. Compared to gargling with providone-iodine and amphotericin B, the Syousaikotou gargle showed a significantly decreased incidence of stomatitis, and a painkilling effect. Stomatitis occurred in about 17.4% among 23 chemotherapy cycles with the Syousaikotou gargle, against about 40.8% among 71 chemotherapy cycles without the Syousaikotou gargle. Among the patients suffering stomatitis pain after 22 chemotherapy cycles, the painkilling effect was seen to be 76.2%, and continues for about 2 hours. Critical side effects were not seen, but in 4 cases there were complaints about foul smells, such as oil and grass smells. Syousaikotou gargle was considered to be one of the useful methods against the stomatitis prevention and sharp pain mitigation from the chemotherapy.
化疗伴随的口腔炎会降低患者的生活质量。许多报告表明，某些用于口腔黏膜炎的含漱剂可缩短症状持续时间并减轻症状严重程度。本研究测试了一种草药（小柴胡汤）作为含漱剂对接受化疗患者口腔炎的预防作用和疗效。与使用聚维酮碘和两性霉素B含漱相比，小柴胡汤含漱剂的口腔炎发生率显著降低，且具有止痛效果。在23个使用小柴胡汤含漱剂的化疗周期中，口腔炎发生率约为17.4%，而在71个未使用小柴胡汤含漱剂的化疗周期中，发生率约为40.8%。在22个化疗周期后出现口腔炎疼痛的患者中，止痛效果达76.2%，且持续约2小时。未观察到严重副作用，但有4例出现诸如油味和草味等异味投诉。小柴胡汤含漱剂被认为是预防化疗引起的口腔炎和减轻剧痛的有效方法之一。
