泛素：结构、功能及作用机制

Ubiquitin: structures, functions, mechanisms.

作者信息

Pickart Cecile M, Eddins Michael J

机构信息

Department of Biochemistry and Molecular Biology/Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA.

出版信息

Biochim Biophys Acta. 2004 Nov 29;1695(1-3):55-72. doi: 10.1016/j.bbamcr.2004.09.019.

DOI:10.1016/j.bbamcr.2004.09.019

PMID:15571809

Abstract

Ubiquitin is the founding member of a family of structurally conserved proteins that regulate a host of processes in eukaryotic cells. Ubiquitin and its relatives carry out their functions through covalent attachment to other cellular proteins, thereby changing the stability, localization, or activity of the target protein. This article reviews the basic biochemistry of these protein conjugation reactions, focusing on ubiquitin itself and emphasizing recent insights into mechanism and specificity.

摘要

泛素是一类结构保守的蛋白质家族的创始成员，这些蛋白质调节真核细胞中的许多过程。泛素及其相关蛋白通过与其他细胞蛋白共价连接来发挥其功能，从而改变靶蛋白的稳定性、定位或活性。本文综述了这些蛋白质缀合反应的基本生物化学，重点关注泛素本身，并强调了对机制和特异性的最新见解。