Cardozo Timothy, Pagano Michele
Department of Pathology and New York University Cancer Institute, New York University Medical Center, 550 First Avenue, MSB 599, New York, New York 10016, USA.
Nat Rev Mol Cell Biol. 2004 Sep;5(9):739-51. doi: 10.1038/nrm1471.
Ubiquitin ligases are well suited to regulate molecular networks that operate on a post-translational timescale. The F-box family of proteins - which are the substrate-recognition components of the Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase - are important players in many mammalian functions. Here we explore a unifying and structurally detailed view of SCF-mediated proteolytic control of cellular processes that has been revealed by recent studies.
泛素连接酶非常适合调控在翻译后时间尺度上运作的分子网络。F-box蛋白家族——作为Skp1-Cul1-F-box蛋白（SCF）泛素连接酶的底物识别成分——在许多哺乳动物功能中发挥着重要作用。在此，我们探讨了近期研究所揭示的关于SCF介导的细胞过程蛋白水解控制的统一且结构详细的观点。
