Herzog Michael H, Kopmann Sabine, Brand Andreas
Laboratory of Psycophysics, Brain Mind Institute, EPFL, 1015 Lausanne, Switzerland.
Psychiatry Res. 2004 Nov 30;129(1):55-63. doi: 10.1016/j.psychres.2004.06.008.
As revealed by backward masking studies, schizophrenic patients show strong impairments of early visual processing. However, the underlying temporal mechanisms are not yet well understood. To shed light on the exact timing of these deficits, we employed a paradigm in which two masks follow each other. We investigated 16 medicated schizophrenic patients and a matched group of 14 controls with a new backward masking technique, shine-through. In accordance with other masking studies, schizophrenic patients require a dramatically longer processing time to reach a predefined performance level compared with healthy subjects. However, patients are surprisingly sensitive to subtle differences in the timing of the two masks, revealing good temporal resolution. This good temporal resolution indicates intact and fast perceptual grouping and figure-ground segmentation in spite of high susceptibility to masking procedures in schizophrenia.
如反向掩蔽研究所示,精神分裂症患者在早期视觉处理方面存在严重缺陷。然而,其潜在的时间机制尚未得到充分理解。为了阐明这些缺陷的确切时间点,我们采用了一种两个掩蔽相继出现的范式。我们用一种新的反向掩蔽技术——穿透掩蔽,对16名接受药物治疗的精神分裂症患者和14名相匹配的对照组进行了研究。与其他掩蔽研究一致,与健康受试者相比,精神分裂症患者需要显著更长的处理时间才能达到预定的表现水平。然而,患者对两个掩蔽时间上的细微差异出奇地敏感,显示出良好的时间分辨率。这种良好的时间分辨率表明,尽管精神分裂症患者对掩蔽程序高度敏感,但他们的知觉分组和图形-背景分割功能完整且快速。