当糖类引导轴突时：硫酸乙酰肝素蛋白聚糖突变体的启示

When sugars guide axons: insights from heparan sulphate proteoglycan mutants.

作者信息

Lee Jeong-Soo, Chien Chi-Bin

机构信息

Department of Neurobiology and Anatomy, University of Utah School of Medicine, 20 North 1900 East, Salt Lake City, Utah 84132, USA.

出版信息

Nat Rev Genet. 2004 Dec;5(12):923-35. doi: 10.1038/nrg1490.

DOI:10.1038/nrg1490

PMID:15573124

Abstract

Although there have previously been hints that heparan sulphate proteoglycans (HSPGs) are important for axon guidance, as they are for many other biological processes, there has been little in vivo evidence for interaction with known axon-guidance pathways. Genetic analyses of fly, mouse, nematode and zebrafish mutants now confirm the role of HSPGs in axon guidance and are beginning to show that they might have a key role in modulating the action of axon-guidance ligands and receptors.

摘要

尽管此前已有线索表明硫酸乙酰肝素蛋白聚糖（HSPGs）对轴突导向很重要，就像它们在许多其他生物过程中一样，但几乎没有体内证据表明其与已知的轴突导向通路存在相互作用。对果蝇、小鼠、线虫和斑马鱼突变体的遗传分析现已证实HSPGs在轴突导向中的作用，并开始表明它们可能在调节轴突导向配体和受体的作用中起关键作用。