Häcker Udo, Nybakken Kent, Perrimon Norbert
Department of Experimental Medical Science, Lund Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden.
Nat Rev Mol Cell Biol. 2005 Jul;6(7):530-41. doi: 10.1038/nrm1681.
Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. Genetic experiments have identified heparan sulphate proteoglycans (HSPGs) as important regulators of the tissue distribution of these extracellular signalling molecules. Several recent reports provide important new insights into the mechanisms by which HSPGs function during development.
发育过程中的模式形成在很大程度上受少数保守的信号转导通路控制，这些通路由细胞外配体激活，如刺猬蛋白、无翅蛋白或果蝇的Dpp蛋白。遗传学实验已确定硫酸乙酰肝素蛋白聚糖（HSPG）是这些细胞外信号分子组织分布的重要调节因子。最近的几份报告为HSPG在发育过程中发挥作用的机制提供了重要的新见解。
