Gabrilovich Dmitry
H. Lee Moffitt Cancer Center, University of South Florida, MRC 2067, 12902 Magnolia Drive, Tampa, Florida 33612, USA.
Nat Rev Immunol. 2004 Dec;4(12):941-52. doi: 10.1038/nri1498.
The failure of the immune system to provide protection against tumour cells is an important immunological problem. It is now evident that inadequate function of the host immune system is one of the main mechanisms by which tumours escape from immune control, as well as an important factor that limits the success of cancer immunotherapy. In recent years, it has become increasingly clear that defects in dendritic cells have a crucial role in non-responsiveness to tumours. This article focuses on the functional consequences and recently described mechanisms of the dendritic-cell defects in cancer.
免疫系统无法对肿瘤细胞提供保护是一个重要的免疫学问题。现在很明显，宿主免疫系统功能不足是肿瘤逃避免疫控制的主要机制之一，也是限制癌症免疫治疗成功的一个重要因素。近年来，越来越清楚的是，树突状细胞缺陷在对肿瘤的无反应性中起关键作用。本文重点关注癌症中树突状细胞缺陷的功能后果及最近描述的机制。
