减数分裂：细胞周期调控重新洗牌并进行分配。

Meiosis: cell-cycle controls shuffle and deal.

作者信息

Marston Adèle L, Amon Angelika

机构信息

Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, 40 Ames Street, Cambridge, Massachusetts 02139, USA.

出版信息

Nat Rev Mol Cell Biol. 2004 Dec;5(12):983-97. doi: 10.1038/nrm1526.

DOI:10.1038/nrm1526

PMID:15573136

Abstract

Meiosis is the type of cell division that gives rise to eggs and sperm. Errors in the execution of this process can result in the generation of aneuploid gametes, which are associated with birth defects and infertility in humans. Here, we review recent findings on how cell-cycle controls ensure the coordination of meiotic events, with a particular focus on the segregation of chromosomes.

摘要

减数分裂是产生卵子和精子的细胞分裂类型。这一过程执行过程中的错误会导致非整倍体配子的产生，而这与人类的出生缺陷和不孕不育有关。在此，我们综述了关于细胞周期调控如何确保减数分裂事件协调进行的最新研究发现，尤其着重于染色体的分离。