Tjandra Joe J, Lim Jit Fong, Matzel Klaus
Department of Colorectal Surgery, Royal Melbourne Hospital and Epworth Hospital, Melbourne, Australia.
ANZ J Surg. 2004 Dec;74(12):1098-106. doi: 10.1111/j.1445-1433.2004.03259.x.
Faecal incontinence is common, distressing to the patient and socially incapacitating. The treatment options depend on the severity and aetiology of incontinence. For mild cases of faecal incontinence, medical management and pelvic floor physiotherapy may be adequate. For more severe cases, surgery is often required. Patients who have a distinct sphincter defect are amenable to surgical repair. In many cases, there is a combination of diffuse structural damage of the anal sphincters with pudendal neuropathy. Conventional surgical repairs have a modest degree of success and the results tend to deteriorate with time. Neosphincter procedures such as artificial bowel sphincter and dynamic graciloplasty are potentially morbid and technically complex. Sacral nerve stimulation is innovative and has had a medium-term success with improvement of quality of life in over 80% of patients treated for faecal incontinence. These results are superior to other techniques in treating patients with severe refractory faecal incontinence, where current maximal therapy has failed. The technique is unique because there is a screening phase, which has a high predictive value. It is also associated with minimal complications that are usually minor. However, most published reports of sacral nerve stimulation for treatment of faecal incontinence were case studies and methods of assessing outcome were variable. Criteria for patient selection are evolving and are yet to be defined. The present paper critically reviews the publications to date on sacral nerve stimulation for treatment of faecal incontinence. This will form the basis for future evaluation of this emerging treatment of severe, intractable faecal incontinence. Randomized clinical trials like that of the Melbourne trial will further clarify the role and indications of sacral nerve stimulation for faecal incontinence.
大便失禁很常见,给患者带来痛苦,且会导致社交障碍。治疗方案取决于失禁的严重程度和病因。对于轻度大便失禁病例,药物治疗和盆底物理治疗可能就足够了。对于更严重的病例,则通常需要手术治疗。有明显括约肌缺陷的患者适合进行手术修复。在许多情况下,肛门括约肌存在弥漫性结构损伤并伴有阴部神经病变。传统的手术修复成功率一般,而且结果往往会随着时间推移而恶化。新括约肌手术,如人工肠括约肌和动态股薄肌成形术,可能存在风险且技术复杂。骶神经刺激是一种创新方法,在超过80%接受治疗的大便失禁患者中,中期取得了改善生活质量的成功。在治疗严重难治性大便失禁且当前最大程度治疗失败的患者方面,这些结果优于其他技术。该技术独特之处在于有一个筛查阶段,其预测价值很高。它还伴有极少的并发症,通常都不严重。然而,大多数已发表的关于骶神经刺激治疗大便失禁的报告都是病例研究,评估结果的方法各不相同。患者选择标准正在不断发展,尚未明确。本文对迄今为止关于骶神经刺激治疗大便失禁的出版物进行了批判性综述。这将为未来评估这种新兴的严重顽固性大便失禁治疗方法奠定基础。像墨尔本试验那样的随机临床试验将进一步阐明骶神经刺激在大便失禁治疗中的作用和适应症。