Reigl Markus, Alon Uri, Chklovskii Dmitri B
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
BMC Biol. 2004 Dec 2;2:25. doi: 10.1186/1741-7007-2-25.
Does the C. elegans nervous system contain multi-neuron computational modules that perform stereotypical functions? We attempt to answer this question by searching for recurring multi-neuron inter-connectivity patterns in the C. elegans nervous system's wiring diagram.
Our statistical analysis reveals that some inter-connectivity patterns containing two, three and four (but not five) neurons are significantly over-represented relative to the expectations based on the statistics of smaller inter-connectivity patterns.
Over-represented patterns (or motifs) are candidates for computational modules that may perform stereotypical functions in the C. elegans nervous system. These modules may appear in other species and need to be investigated further.
秀丽隐杆线虫的神经系统是否包含执行刻板功能的多神经元计算模块？我们试图通过在秀丽隐杆线虫神经系统的接线图中寻找反复出现的多神经元互连模式来回答这个问题。
我们的统计分析表明，一些包含两个、三个和四个（但不包括五个）神经元的互连模式相对于基于较小互连模式统计的预期显著过度呈现。
过度呈现的模式（或基序）是可能在秀丽隐杆线虫神经系统中执行刻板功能的计算模块的候选者。这些模块可能出现在其他物种中，需要进一步研究。
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