Zaĭrat'iants O V, Kolobov S V, Akopian I G, Opalenov K V, Barsanova T G
Arkh Patol. 2004 Sep-Oct;66(5):9-12.
Breast cell carcinomas removed from 62 women aged from 33 to 74 years were studied immunohistochemically. 24 tumours were of T1N0M0, 5-T1N1M0, 20-T2N0M0, 11-T2N1M0 and 2-T2N0M0. Invasive ductal carcinoma occurred in 59.6%, invasive ductal in 40.4%. Estrogen receptor expression was found in 59.6%, progesterone in 38.7%. Simultaneous expression of these receptors was in 35.5%. Estrogen receptor and progesterone receptor expression were registered in 24.2 and 3.2% cases, respectively. There was neither estrogen nor progesterone expression in 37%. HER-2 expression was observed in 45.2%, the highest being at the age from 50 to 55 years and in invasive ductal carcinoma. Enhancement of estrogen receptor expression was accompanied with lower rate of HER-2 expression. All three antigens expression does not depend on the presence or absence of metastases to the regional lymph nodes.
对62名年龄在33至74岁之间的女性切除的乳腺细胞癌进行了免疫组织化学研究。24例肿瘤为T1N0M0，5例为T1N1M0，20例为T2N0M0，11例为T2N1M0，2例为T2N0M0。浸润性导管癌占59.6%，浸润性小叶癌占40.4%。雌激素受体表达率为59.6%，孕激素受体表达率为38.7%。这些受体的同时表达率为35.5%。雌激素受体和孕激素受体单独表达率分别为24.2%和3.2%。37%的病例既无雌激素表达也无孕激素表达。HER-2表达率为45.2%，在50至55岁年龄段及浸润性导管癌中最高。雌激素受体表达增强伴随着HER-2表达率降低。所有三种抗原的表达均不取决于区域淋巴结有无转移。
