Brzezińska Elzbieta, Stolarska Justyna
Department of Analytical Chemistry, Medical University of Lódź, 1 Muszyńskiego Str., 90-151 Lódź, Poland.
Acta Pol Pharm. 2004 Jul-Aug;61(4):249-54.
We performed QSAR analysis of beta2-adrenergic activity and chromatographic data of 4,6,8-trihydroxy-, 6,7-dihydroxy- and 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives. TLC plates (silica gel NP 60F(254) and silica gel RP2 60F(254) silanised precoated), impregnated with solutions of analogues of the selected amino acids were used as beta2-agonistic and antagonistic interaction models. QSAR analysis of the beta2-adrenergic activity and the chromatographic data of the solutes were made. A correlation between biological data and behaviour of the examined compounds in a chromatographic modifiable environment (S1-S3) was investigated by the linear regression analysis method.
我们对4,6,8-三羟基-、6,7-二羟基-和6,7-二甲氧基-1,2,3,4-四氢异喹啉衍生物的β2-肾上腺素能活性和色谱数据进行了定量构效关系（QSAR）分析。用浸渍有所选氨基酸类似物溶液的薄层色谱板（硅胶NP 60F(254)和硅胶RP2 60F(254)硅烷化预涂板）作为β2-激动剂和拮抗剂相互作用模型。对β2-肾上腺素能活性和溶质的色谱数据进行了QSAR分析。采用线性回归分析方法研究了生物学数据与被检测化合物在色谱可变环境（S1-S3）中的行为之间的相关性。
