Øymar K, Aksnes L
Department of Pediatrics, Rogaland Central Hospital, Stavanger, Norway.
Allergy. 2005 Jan;60(1):86-9. doi: 10.1111/j.1398-9995.2005.00658.x.
Leukotrienes are thought to play a role in the pathogenesis of atopic eczema/dermatitis syndrome (AEDS). Urinary leukotriene E4 (U-LTE4) is a marker of whole-body cysteinyl-leukotriene production.
To evaluate the role of leukotrienes in children with AEDS by measuring levels of U-LTE4, and to evaluate whether levels of U-LTE4 may reflect disease activity and allergic sensitization in AEDS.
U-LTE4 was measured by enzyme-linked immunosorbent assay in 87 children with mild (n=32), moderate (n=34) and severe (n=21) AEDS, as well as in 72 nonatopic healthy controls. Fifty-eight of the children with AEDS were sensitized to common allergens, and 29 were not.
Levels of U-LTE4 were higher in children with severe AEDS (140; 66-166 microg/mmol creatinine, median; quartiles) than in controls (52; 30-90, P <0.05), whereas levels of U-LTE4 in moderate and mild disease were similar to controls. U-LTE4 levels were similar in children with or without sensitization to common allergens, but severe AEDS children with sensitization had higher levels of U-LTE4 than those without sensitization.
The results suggest a role for leukotrienes in the pathogenesis of severe AEDS, and may support a role for leukotriene-antagonists in the treatment of this disorder. Levels of U-LTE4 may reflect the disease severity and sensitization to allergens in AEDS.
白三烯被认为在特应性湿疹/皮炎综合征（AEDS）的发病机制中起作用。尿白三烯E4（U-LTE4）是全身半胱氨酰白三烯产生的标志物。
通过测量U-LTE4水平评估白三烯在AEDS患儿中的作用，并评估U-LTE4水平是否可反映AEDS的疾病活动和过敏致敏情况。
采用酶联免疫吸附测定法测量87例轻度（n = 32）、中度（n = 34）和重度（n = 21）AEDS患儿以及72例非特应性健康对照者的U-LTE4水平。87例AEDS患儿中，58例对常见变应原致敏，29例未致敏。
重度AEDS患儿的U-LTE4水平（中位数为140；四分位数为66 - 166μg/mmol肌酐）高于对照组（中位数为52；四分位数为30 - 90，P < 0.05），而中度和轻度疾病患儿的U-LTE4水平与对照组相似。对常见变应原致敏或未致敏的患儿U-LTE4水平相似，但重度AEDS致敏患儿的U-LTE4水平高于未致敏患儿。
结果提示白三烯在重度AEDS发病机制中起作用，并可能支持白三烯拮抗剂在该疾病治疗中的作用。U-LTE4水平可能反映AEDS的疾病严重程度和对变应原的致敏情况。
