Inoue Yutaka, Ito Kazuhiko, Sakaue Takahiro, Iwamoto Takahiro, Kita Satomi
Laboratory for Discovery Research, Pharmaceutical Research & Development Division, Senju Pharmaceutical Co. Ltd.
Clin Calcium. 2004 Aug;14(8):84-91.
Recently, we developed 2-(4- [4-nitrobenzyloxy] benzyl) thiazolidine-4-carboxylic acid ethyl ester (SN-6), a newly synthesized and selective inhibitor of Na(+)/Ca(2+) exchanger. SN-6 is a selective inhibitor for the Ca(2+) influx mode of Na(+)/Ca(2+) exchanger. And this compound attenuated hypoxia/reoxygenation-induced renal tubular cell damage and ischemia/reperfusion-induced renal failure. These results suggest that SN-6 is expected to be pharmacological tools to study the roles of the exchanger and a new anti-ischemic drug.
最近，我们研发了2-(4-[4-硝基苄氧基]苄基)噻唑烷-4-羧酸乙酯（SN-6），一种新合成的Na(+)/Ca(2+)交换体选择性抑制剂。SN-6是Na(+)/Ca(2+)交换体Ca(2+)内流模式的选择性抑制剂。并且该化合物减轻了缺氧/复氧诱导的肾小管细胞损伤以及缺血/再灌注诱导的肾衰竭。这些结果表明，SN-6有望成为研究该交换体作用的药理学工具以及一种新型抗缺血药物。
