Kurebayashi Junichi
Department of Breast & Thyroid Surgery, Kawasaki Medical School.
Clin Calcium. 2004 Oct;14(10):47-51.
One of selective estrogen receptor modulators (SERMs), tamoxifen, has been widely used for prevention of breast cancer, postoperative adjuvant therapy and treatment of advanced breast cancer. The relation of a long-term administration of tamoxifen and its adverse effects have been extensively investigated. Favorable effects of tamoxifen are:the reduction in the risk of contralateral breast cancer, gain in bone density in postmenopausal women and decrease in serum low-density lipoprotein cholesterol. Unfavorable effects are: gynecologic problems and the increase in the risk of endometrial cancer and thromboembolism. In contrast, another SERM, raloxifene, has reported to have similar favorable adverse effects but no unfavorable effect on endometrium.
选择性雌激素受体调节剂（SERM）之一的他莫昔芬已被广泛用于预防乳腺癌、术后辅助治疗及晚期乳腺癌的治疗。长期服用他莫昔芬及其不良反应的关系已得到广泛研究。他莫昔芬的有益作用包括：降低对侧乳腺癌风险、增加绝经后女性骨密度以及降低血清低密度脂蛋白胆固醇水平。不利影响包括：妇科问题、子宫内膜癌风险增加以及血栓栓塞。相比之下，另一种SERM雷洛昔芬据报道具有类似的有益不良反应，但对子宫内膜无不利影响。
