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选择性雌激素受体调节剂对乳腺癌和心血管疾病的影响:比较雷洛昔芬与激素替代疗法对这些疾病风险的影响

[Effects of SERM on breast cancer and cardiovascular disease: making a comparison between raloxifene use and hormone replacement therapy on the risks of the diseases].

作者信息

Higuchi Tsuyoshi, Mizunuma Hideki

机构信息

Department of OB/GYN, Hirosaki University School of Medicine.

出版信息

Clin Calcium. 2004 Oct;14(10):81-4.

Abstract

According to the report of MORE trial, raloxifene (RLX) compensate for the faults of hormone replacement therapy with the reasons following below; 1) RLX inhibits onset of breast cancer with estrogen receptor remarkably, 2) RLX inhibits onset of cardiovascular disease in its high risk group. However, because RLX has a elevated risk of venous thrombosis as same as hormone replacement therapy, we should give attention to this disease at the use of RLX.

摘要

根据MORE试验报告,雷洛昔芬(RLX)弥补了激素替代疗法的不足,原因如下:1)RLX能显著抑制雌激素受体阳性乳腺癌的发生;2)RLX能抑制高危人群心血管疾病的发生。然而,由于RLX与激素替代疗法一样存在静脉血栓形成风险增加的问题,在使用RLX时应关注这一疾病。

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