Higuchi Tsuyoshi, Mizunuma Hideki
Department of OB/GYN, Hirosaki University School of Medicine.
Clin Calcium. 2004 Oct;14(10):81-4.
According to the report of MORE trial, raloxifene (RLX) compensate for the faults of hormone replacement therapy with the reasons following below; 1) RLX inhibits onset of breast cancer with estrogen receptor remarkably, 2) RLX inhibits onset of cardiovascular disease in its high risk group. However, because RLX has a elevated risk of venous thrombosis as same as hormone replacement therapy, we should give attention to this disease at the use of RLX.
根据MORE试验报告,雷洛昔芬(RLX)弥补了激素替代疗法的不足,原因如下:1)RLX能显著抑制雌激素受体阳性乳腺癌的发生;2)RLX能抑制高危人群心血管疾病的发生。然而,由于RLX与激素替代疗法一样存在静脉血栓形成风险增加的问题,在使用RLX时应关注这一疾病。