Beq Stéphanie, Fontanet Arnaud, Theze Jacques, Colle Jean-Hervé
Unité d'ImmunoGénétique Cellulaire, Institut Pasteur, Paris, France.
AIDS. 2004 Oct 21;18(15):2089-91. doi: 10.1097/00002030-200410210-00016.
IL-2 is used in conjunction with highly active antiretroviral therapy to increase the CD4 cell count in HIV-positive patients. The mechanisms involved remain ill-defined. Here we show that during the first cycle of IL-2 therapy, IL-7 and Flt-3L plasma levels are increased, whereas levels of stem cell factor are unchanged. This supports the hypothesis that aside from stimulating CD4 T cells IL-2 may also indirectly affect lymphocyte production through the stimulation of lymphopoietic cytokines.
白细胞介素-2与高效抗逆转录病毒疗法联合使用，以提高HIV阳性患者的CD4细胞计数。其中涉及的机制仍不明确。在此我们表明，在白细胞介素-2治疗的第一个周期中，血浆白细胞介素-7和Flt-3L水平升高，而干细胞因子水平未变。这支持了这样一种假说，即除了刺激CD4 T细胞外，白细胞介素-2还可能通过刺激淋巴细胞生成细胞因子间接影响淋巴细胞生成。
