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桡侧前臂游离组织移植可减少挽救性颅底手术的并发症。

Radial forearm free tissue transfer reduces complications in salvage skull base surgery.

作者信息

Chepeha Douglas B, Wang Steven J, Marentette Lawrence J, Thompson Byron G, Prince Mark E, Teknos Theodoros N

机构信息

Department of Otolaryngology--Head and Neck Surgery, University of Michigan Health System, Ann Arbor 48109-0312, USA.

出版信息

Otolaryngol Head Neck Surg. 2004 Dec;131(6):958-63. doi: 10.1016/j.otohns.2004.05.029.

DOI:10.1016/j.otohns.2004.05.029
PMID:15577797
Abstract

OBJECTIVE

Patients who undergo skull base resection after prior surgery or radiation may be at high risk for complications when local flaps alone are used for reconstruction. To determine whether the complication rate could be reduced, fasciocutaneous free tissue transfer was used to reinforce the dural closure in patients who had prior skull base surgery or radiation.

METHODS

This study is a case series of 20 patients (14 males, 6 females, aged 8-79 years of age with a mean of 47.7 years) from 1997 to 2001 who had prior skull base surgery or radiation, and underwent salvage skull base resection without large volume defects. All patients had a radial forearm free tissue transfer to reinforce the dural closure. Six patients had an osseous component to the forearm flap to provide vascularized bone to the orbital rim.

RESULTS

The overall local complication rate was 35%. Three patients (15%) had major complications including 1 case of meningitis, 1 case of cerebrospinal fluid leak, and 1 case of a flap requiring venous salvage. There were no flap failures, 1 idiopathic median nerve palsy, and no pathologic radius bone fractures.

CONCLUSION

Reconstruction with fasciocutaneous free tissue transfer for high-risk patients with low-volume dural defects following skull base resection can minimize the risk of major postoperative complications.

EBM RATING

C.

摘要

目的

既往接受过手术或放疗后又进行颅底切除术的患者,若仅使用局部皮瓣进行重建,发生并发症的风险可能很高。为了确定并发症发生率是否能够降低,对既往接受过颅底手术或放疗的患者,采用游离筋膜皮瓣组织转移来加强硬脑膜闭合。

方法

本研究是一项病例系列研究,纳入了1997年至2001年间的20例患者(14例男性,6例女性,年龄8 - 79岁,平均47.7岁),这些患者既往接受过颅底手术或放疗,且在进行挽救性颅底切除术后时没有没有大面积缺损。所有患者均采用桡侧前臂游离组织转移来加强硬脑膜闭合。6例患者的前臂皮瓣带有骨性成分,用于为眶缘提供带血管的骨组织。

结果

总体局部并发症发生率为35%。3例患者(15%)发生了严重并发症,包括1例脑膜炎、1例脑脊液漏和1例需要进行静脉挽救的皮瓣。没有皮瓣坏死、1例特发性正中神经麻痹,也没有桡骨病理性骨折。

结论

对于颅底切除术后硬脑膜缺损较小的高危患者,采用游离筋膜皮瓣组织转移进行重建可将术后严重并发症的风险降至最低。

循证医学评级

C级。

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