高效抗逆转录病毒治疗期间与卡波西肉瘤相关的免疫重建炎症综合征。

Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma during potent antiretroviral therapy.

作者信息

Connick Elizabeth, Kane Madeleine A, White Irene E, Ryder John, Campbell Thomas B

机构信息

Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver 80262, USA.

出版信息

Clin Infect Dis. 2004 Dec 15;39(12):1852-5. doi: 10.1086/426078. Epub 2004 Nov 19.

DOI:10.1086/426078

PMID:15578411

Abstract

Rapidly progressive Kaposi sarcoma (KS) lesions with lymphadenopathy and tissue swelling occurred in a patient during antiretroviral treatment, despite an increased CD4(+) lymphocyte count and decreased HIV-1 level and KS-associated herpesvirus replication, suggesting immune reconstitution inflammatory syndrome. Inflammation resolved coincident with decreases in the CD4(+) lymphocyte count during paclitaxel treatment, whereas KS cleared only after prolonged antiretroviral therapy and chemotherapy.

摘要

一名患者在抗逆转录病毒治疗期间出现了伴有淋巴结病和组织肿胀的快速进展性卡波西肉瘤（KS）病变，尽管其CD4(+)淋巴细胞计数增加、HIV-1水平降低且与KS相关的疱疹病毒复制减少，提示存在免疫重建炎症综合征。在紫杉醇治疗期间，炎症随着CD4(+)淋巴细胞计数的下降而消退，而KS仅在长期抗逆转录病毒治疗和化疗后才得以清除。