对艾滋病相关卡波西肉瘤患者诊断前后血清人疱疹病毒8型病毒DNA载量进行回顾性纵向分析。
Retrospective, longitudinal analysis of serum human herpesvirus-8 viral DNA load in AIDS-related Kaposi's sarcoma patients before and after diagnosis.
作者信息
Polstra Abeltje M, Cornelissen Marion, Goudsmit Jaap, van der Kuyl Antoinette C
机构信息
Department of Human Retrovirology, Academic Medical Centre, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands.
出版信息
J Med Virol. 2004 Nov;74(3):390-6. doi: 10.1002/jmv.20192.
Human herpesvirus 8 (HHV-8) is detected more often in patients progressing towards Kaposi's sarcoma (KS) than in patients who do not develop the disease, suggesting that the level of viremia might be associated with Kaposi's sarcoma disease and progression. Longitudinal serum samples from 19 AIDS-Kaposi's sarcoma patients, ranging from 2 years before KS till 2 years after KS diagnosis were tested. No correlation was found between viral load and progression to KS, or disease stage.
与未患卡波西肉瘤（KS）的患者相比，在进展为卡波西肉瘤的患者中更常检测到人类疱疹病毒8（HHV - 8），这表明病毒血症水平可能与卡波西肉瘤疾病及其进展有关。对19例艾滋病相关卡波西肉瘤患者从KS发生前2年到KS诊断后2年的纵向血清样本进行了检测。未发现病毒载量与进展为KS或疾病分期之间存在相关性。
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