Williams Sophie, Isaac Graham, Hatto Peter, Stone Martin H, Ingham Eileen, Fisher John
Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, UK.
J Arthroplasty. 2004 Dec;19(8 Suppl 3):112-7. doi: 10.1016/j.arth.2004.09.014.
Metal-on-metal hip arthroplasties have demonstrated low wear rates. However, the ion release and toxicity of the metal wear particles remains a concern. Modifying the surface of metal bearings with thick chromium nitride (CrN) coatings has the potential to further reduce wear and ion release, and improve the biocompatibility of wear particles produced. The aim of this study was to investigate the application of surface engineering technology to modify metal-on-metal (MOM) bearings to reduce wear and improve the functional biocompatibility of metal-on-metal prostheses. CrN-on-CrN bearings had lower wear rates in comparison to metal-on-metal bearings, particularly under adverse loading conditions. CrN-on-CrN bearings produced similar nanometer-sized particles to metal-on-metal bearings, however, CrN wear particles were less cytotoxic when cocultured with macrophage and fibroblast cells.
金属对金属髋关节置换术已显示出较低的磨损率。然而，金属磨损颗粒的离子释放和毒性仍然是一个令人担忧的问题。用厚氮化铬（CrN）涂层修饰金属轴承表面有可能进一步减少磨损和离子释放，并改善所产生磨损颗粒的生物相容性。本研究的目的是探讨表面工程技术在修饰金属对金属（MOM）轴承以减少磨损和改善金属对金属假体功能生物相容性方面的应用。与金属对金属轴承相比，CrN对CrN轴承具有更低的磨损率，特别是在不利的负载条件下。CrN对CrN轴承产生的纳米级颗粒与金属对金属轴承相似，然而，当与巨噬细胞和成纤维细胞共培养时，CrN磨损颗粒的细胞毒性较小。
