印记基因和母体效应基因的复杂相互作用改变了奇数性（Ods）小鼠的性别决定。
A complex interaction of imprinted and maternal-effect genes modifies sex determination in Odd Sex (Ods) mice.
作者信息
Poirier Christophe, Qin Yangjun, Adams Carolyn P, Anaya Yanett, Singer Jonathan B, Hill Annie E, Lander Eric S, Nadeau Joseph H, Bishop Colin E
机构信息
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA.
出版信息
Genetics. 2004 Nov;168(3):1557-62. doi: 10.1534/genetics.104.032177.
The transgenic insertional mouse mutation Odd Sex (Ods) represents a model for the long-range regulation of Sox9. The mutation causes complete female-to-male sex reversal by inducing a male-specific expression pattern of Sox9 in XX Ods/+ embryonic gonads. We previously described an A/J strain-specific suppressor of Ods termed Odsm1(A). Here we show that phenotypic sex depends on a complex interaction between the suppressor and the transgene. Suppression can be achieved only if the transgene is transmitted paternally. In addition, the suppressor itself exhibits a maternal effect, suggesting that it may act on chromatin in the early embryo.
转基因插入小鼠突变体“奇特性别”（Odd Sex，Ods）代表了一种Sox9基因远程调控的模型。该突变通过在XX Ods/+胚胎性腺中诱导Sox9的雄性特异性表达模式，导致完全的雌性向雄性性反转。我们之前描述了一种名为Odsm1(A)的Ods的A/J品系特异性抑制因子。在此我们表明，表型性别取决于抑制因子与转基因之间的复杂相互作用。只有当转基因通过父系传递时才能实现抑制。此外，抑制因子本身表现出母系效应，这表明它可能在早期胚胎中作用于染色质。
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