Sox9在XX转基因小鼠中诱导睾丸发育。

Sox9 induces testis development in XX transgenic mice.

作者信息

Vidal V P, Chaboissier M C, de Rooij D G, Schedl A

机构信息

MDC for Molecular Medicine, Robert-Rössle-Strasse 10, 13092 Berlin, Germany.

出版信息

Nat Genet. 2001 Jul;28(3):216-7. doi: 10.1038/90046.

DOI:10.1038/90046

PMID:11431689

Abstract

Mutations in SOX9 are associated with male-to-female sex reversal in humans. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating that it can substitute for the sex-determining gene Sry.

摘要

SOX9基因的突变与人类的男性向女性性反转有关。为了分析Sox9在性别决定过程中的功能，我们在XX性腺中异位表达了该基因。在此，我们表明Sox9足以诱导小鼠睾丸形成，这表明它可以替代性别决定基因Sry。