Sadda Srinivas R, Pieramici Dante J, Marsh Marta J, Bressler Neil M, Bressler Susan B
Doheny Retina Institute, Doheny Eye Institute, Los Angeles, California, USA.
Retina. 2004 Dec;24(6):888-99. doi: 10.1097/00006982-200412000-00008.
To compare the size of subfoveal lesions based on photographic documentation before and after submacular surgery of choroidal neovascularization (CNV) lesions.
Subfoveal lesion sizes at baseline and month 3 follow-up visits for patients assigned to surgery in the Submacular Surgery Trials (SST) Pilot Study were assessed categorically using Macular Photocoagulation Study (MPS) disc area (DA) circles. The Submacular Surgery Trials Pilot Study groups reviewed were as follows: Group N (age-related macular degeneration [AMD]; lesion <50% blood; classic CNV present; size < or =9 MPS DAs); Group R (AMD; prior nonfoveal laser; classic CNV present; size < or =9 MPS DAs); Group B (AMD; lesion > or =50% blood); and Group H (ocular histoplasmosis syndrome or idiopathic; classic CNV present; size < or =9 MPS DAs).
Postoperative month 3 lesion size was at least 1 size category smaller than the preoperative lesion size in 6% (4/66) of Group N, 0 (0/31) of Group R, 6% (2/34) of Group H, and 45% (18/40) of Group B eyes. In Group H eyes, there was no size change in 50% (17/34), and enlargement was found in 44% (15/34). For eyes in Groups N and R, approximately one third remained stable (20/66, 30% and 12/31, 39%, respectively), whereas two thirds enlarged by at least 1 category (42/66, 64% and 19/31, 61%, respectively).
The change in lesion size after submacular surgery was variable, with a tendency for Group H lesions to remain the same size or larger, Group B lesions to measure smaller, and Group N and Group R lesions to be larger.
基于脉络膜新生血管（CNV）病变黄斑下手术前后的摄影记录，比较黄斑下病变的大小。
在黄斑下手术试验（SST）试点研究中，对分配接受手术的患者在基线和随访3个月时的黄斑下病变大小，使用黄斑光凝研究（MPS）视盘面积（DA）圈进行分类评估。所回顾的黄斑下手术试验试点研究组如下：N组（年龄相关性黄斑变性[AMD]；病变血液含量<50%；存在典型CNV；大小≤9个MPS DA）；R组（AMD；既往非黄斑区激光治疗；存在典型CNV；大小≤9个MPS DA）；B组（AMD；病变血液含量≥50%）；H组（眼组织胞浆菌病综合征或特发性；存在典型CNV；大小≤9个MPS DA）。
术后3个月时，N组6%（4/66）、R组0（0/31）、H组6%（2/34）以及B组45%（18/40）的患眼病变大小至少比术前病变大小小1个尺寸类别。在H组患眼中，50%（17/34）大小无变化，44%（15/34）出现增大。对于N组和R组的患眼，约三分之一保持稳定（分别为20/66，30%和12/31，39%），而三分之二至少增大1个类别（分别为42/66，64%和19/31，61%）。
黄斑下手术后病变大小的变化是可变的，H组病变倾向于保持相同大小或增大，B组病变变小，N组和R组病变变大。
