Cortis Elisabetta, De Benedetti Fabrizio, Insalaco Antonella, Cioschi Stefania, Muratori Flaminia, D'Urbano Leila E, Ugazio Alberto G
Department of Medicine, Division of Rheumathology and Laboratory of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.
J Pediatr. 2004 Dec;145(6):851-5. doi: 10.1016/j.jpeds.2004.08.001.
We report a family with pyogenic sterile arthritis, pyoderna and acne syndrome (PAPA). The proband presented several episodes of sterile pyogenic arthritis and became unresponsive to glucocorticoids. After treatment with the tumor necrosis factor inhibitor etanercept, the disease underwent rapid and sustained clinical remission. Production of tumor necrosis factor-alpha by mononuclear cells of the proband and of the affected relatives was abnormally elevated.
我们报告了一个患有化脓性无菌性关节炎、脓皮病和痤疮综合征（PAPA）的家族。先证者出现了几次无菌性化脓性关节炎发作，并且对糖皮质激素无反应。在用肿瘤坏死因子抑制剂依那西普治疗后，疾病迅速且持续地临床缓解。先证者及受影响亲属的单核细胞产生肿瘤坏死因子-α异常升高。
