Lehman Thomas J A, Schechter Sharon J, Sundel Robert P, Oliveira Sheila K, Huttenlocher Anna, Onel Karen B
Division of Pediatric Rheumatology, Hospital for Special Surgery, and the Department of Pediatrics, Sanford Weill Medical College of Cornell University, New York, New York, USA.
J Pediatr. 2004 Dec;145(6):856-7. doi: 10.1016/j.jpeds.2004.08.020.
Thirteen children with difficult systemic onset juvenile rheumatoid arthritis were treated with thalidomide. At 6 months, 11 of the 13 were able to reduce their use of prednisone ( P < .002), with a concurrent improvement in erythrocyte sedimentation rate ( P < .0001) and an increase in hemoglobin level ( P < 0.005). Juvenile rheumatoid arthritis improvement scores >/=50% were obtained by 10 of the 13 children.
13名患有严重全身型幼年类风湿性关节炎的儿童接受了沙利度胺治疗。6个月时，13名儿童中有11名能够减少泼尼松的用量（P < 0.002），同时红细胞沉降率有所改善（P < 0.0001），血红蛋白水平升高（P < 0.005）。13名儿童中有10名的幼年类风湿性关节炎改善评分≥50%。
