Yoshinouchi T, Ohtsuki Y, Fujita J, Yamadori I, Bandoh S, Ishida T, Ueda R
Toyokawa City Hospital, Toyokawa, Aichi, Japan.
Rheumatol Int. 2005 Dec;26(2):121-5. doi: 10.1007/s00296-004-0527-0. Epub 2004 Dec 2.
The pathologic patterns of lung involvement were evaluated in 16 patients with rheumatoid arthritis (RA). They consisted of six females and ten males, with a median age of 67.5 years and diagnosed according to the American Rheumatism Association revised criteria. High-resolution computed tomography (HRCT) of the lungs was performed in all patients, and honeycomb formation was apparent in seven. Histopathologically, seven patients were diagnosed with usual interstitial pneumonia (UIP) pattern, seven with nonspecific interstitial pneumonia/fibrosis (NSIP) pattern, and two with UIP/NSIP hybrid pattern. There were no apparent honeycomb formations on HRCT in patients diagnosed with NSIP pattern. In conclusion, the present study demonstrates that NSIP pattern is also a significant histologic classification of interstitial pneumonia associated with RA.
对16例类风湿关节炎（RA）患者的肺部受累病理模式进行了评估。其中包括6名女性和10名男性，中位年龄为67.5岁，均根据美国风湿病协会修订标准进行诊断。所有患者均进行了肺部高分辨率计算机断层扫描（HRCT），其中7例可见蜂窝状形成。组织病理学上，7例患者被诊断为普通间质性肺炎（UIP）模式，7例为非特异性间质性肺炎/纤维化（NSIP）模式，2例为UIP/NSIP混合模式。诊断为NSIP模式的患者HRCT上无明显蜂窝状形成。总之，本研究表明NSIP模式也是与RA相关的间质性肺炎的重要组织学分类。
