Kumar Neeraj, Van Gerpen Jay A, Bower James H, Ahlskog J Eric
Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Mov Disord. 2005 Mar;20(3):342-4. doi: 10.1002/mds.20360.
We assessed the 5-year risk of levodopa-induced dyskinesias by age of Parkinson's disease (PD) onset in a population-based cohort. The medical records linkage system of the Rochester Epidemiology project was used to identify residents of Olmsted County, Minnesota, with incident PD for the period 1976 through 1990. In this population-based study, the 5-year dyskinesia incidence declined with age. With PD onset after 70 years of age, the incidence was 16%. With onset from 40 to 59 years of age, the incidence was higher at 50%. These incidence data may overestimate the functional importance, because patients with minimal or reversible dyskinesias were counted.
我们在一项基于人群的队列研究中，按帕金森病（PD）发病年龄评估了左旋多巴诱发异动症的5年风险。利用罗切斯特流行病学项目的医疗记录链接系统，识别出明尼苏达州奥尔姆斯特德县1976年至1990年期间新发PD的居民。在这项基于人群的研究中，5年异动症发病率随年龄下降。PD发病年龄在70岁以后，发病率为16%。发病年龄在40至59岁之间，发病率较高，为50%。这些发病率数据可能高估了功能重要性，因为纳入了轻度或可逆性异动症患者。
