Donnelly E F
Office of Communicable Diseases, Rhode Island Department of Health, USA.
Med Health R I. 1998 Nov;81(11):373-5.
Lyme disease is a tick-borne spirochetal disease that is common in Rhode Island. The OSP A based vaccine against Lyme disease that has been shown effective in animal models has now been tested by two manufacturers in thousands of people. The vaccines appear to be safe and effective. When the vaccines become available to physicians, there should be strong demand in Rhode Island, especially in the southern part of the state where there is a high degree of public awareness and experience with Lyme disease. Studies of tick populations support surveillance data that show a concentration of risk in Washington County with a trend of expansion inland. Patients who receive the vaccine should be alerted to the likelihood of local reaction and the less likely systemic effects. Additional patient education should include awareness of other tick-borne diseases such as babesiosis, chrlichiosis, and Rocky Mountain Spotted Fever that are not vaccine-preventable. Serologic testing for Lyme disease will be affected by the immune response to the vaccine. These vaccines have not yet been tested in children.
莱姆病是一种由蜱传播的螺旋体病，在罗德岛很常见。基于外膜蛋白A的莱姆病疫苗在动物模型中已显示出有效性，目前两家制造商已在数千人身上进行了测试。这些疫苗似乎安全有效。当疫苗可供医生使用时，罗德岛应该会有强烈需求，尤其是在该州南部，那里公众对莱姆病的认知度高且有相关经历。对蜱虫种群的研究支持监测数据，这些数据显示华盛顿县风险集中且有向内陆扩展的趋势。接种疫苗的患者应被告知可能出现局部反应以及不太可能出现的全身反应。进一步的患者教育应包括让患者了解其他蜱传播疾病，如巴贝斯虫病、人单核细胞埃立克体病和落基山斑疹热，这些疾病无法通过疫苗预防。莱姆病的血清学检测会受到对疫苗免疫反应的影响。这些疫苗尚未在儿童身上进行测试。
