Nived O, Sturfelt G
Department of Rheumatology, University Hospital, Sweden.
Lupus. 2004;13(11):877-9. doi: 10.1191/0961203304lu2027oa.
Complement is involved in the pathogenesis of systemic lupus erythematosus (SLE) and has also a seemingly paradoxical protective role in the development of the disease. Low levels of components within the classical pathway of complement especially C1q, C4 and C3 have a high specificity for SLE diagnosis and should be considered as promising for inclusion in classification criteria of SLE.
补体参与系统性红斑狼疮（SLE）的发病机制，并且在该疾病的发展过程中似乎还具有矛盾的保护作用。补体经典途径中的成分水平较低，尤其是C1q、C4和C3，对SLE诊断具有高度特异性，应被视为有望纳入SLE分类标准。
