Patched1基因的一个新的第一外显子受刺猬信号通路调控而上调，产生一种具有通路抑制功能的蛋白质。

A novel first exon of the Patched1 gene is upregulated by Hedgehog signaling resulting in a protein with pathway inhibitory functions.

作者信息

Shimokawa Takashi, Rahnama Fahimeh, Zaphiropoulos Peter G

机构信息

Department of Biosciences at Novum, Karolinska Institute, Huddinge 141 57, Sweden.

出版信息

FEBS Lett. 2004 Dec 3;578(1-2):157-62. doi: 10.1016/j.febslet.2004.11.006.

DOI:10.1016/j.febslet.2004.11.006

PMID:15581634

Abstract

Patched homolog 1 (PTCH1) is a key component of the Hedgehog (HH) signaling pathway with three alternative first exons, but only exon 1B transcription depending on HH activation. Here, we show that in both human and mouse a novel PTCH1 first exon (1C) is expressed. Exon 1C transcription is upregulated by HH signaling, but the resulting PTCH1-1C protein has a lower capacity for pathway inhibition than PTCH1-1B.

摘要

patched 同源物 1（PTCH1）是刺猬索尼克（HH）信号通路的关键组成部分，有三个可选择的第一外显子，但仅外显子 1B 的转录依赖于 HH 激活。在此，我们表明在人类和小鼠中均表达一种新型的 PTCH1 第一外显子（1C）。外显子 1C 的转录受 HH 信号上调，但产生的 PTCH1-1C 蛋白对通路的抑制能力低于 PTCH1-1B。