Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon, 34134, Republic of Korea.
Exp Mol Med. 2023 Apr;55(4):755-766. doi: 10.1038/s12276-023-00981-7. Epub 2023 Apr 3.
Cells produce multiple mRNAs through alternative splicing, which ensures proteome diversity. Because most human genes undergo alternative splicing, key components of signal transduction pathways are no exception. Cells regulate various signal transduction pathways, including those associated with cell proliferation, development, differentiation, migration, and apoptosis. Since proteins produced through alternative splicing can exhibit diverse biological functions, splicing regulatory mechanisms affect all signal transduction pathways. Studies have demonstrated that proteins generated by the selective combination of exons encoding important domains can enhance or attenuate signal transduction and can stably and precisely regulate various signal transduction pathways. However, aberrant splicing regulation via genetic mutation or abnormal expression of splicing factors negatively affects signal transduction pathways and is associated with the onset and progression of various diseases, including cancer. In this review, we describe the effects of alternative splicing regulation on major signal transduction pathways and highlight the significance of alternative splicing.
细胞通过选择性剪接产生多种 mRNA，这确保了蛋白质组的多样性。由于大多数人类基因都经历了选择性剪接，信号转导途径的关键组成部分也不例外。细胞调节各种信号转导途径，包括与细胞增殖、发育、分化、迁移和凋亡相关的途径。由于通过选择性剪接产生的蛋白质可以表现出多种生物学功能，因此剪接调控机制会影响所有信号转导途径。研究表明，通过选择性组合编码重要结构域的外显子产生的蛋白质可以增强或减弱信号转导，并可以稳定且精确地调节各种信号转导途径。然而，通过遗传突变或剪接因子异常表达进行的异常剪接调控会对信号转导途径产生负面影响，并与各种疾病（包括癌症）的发生和发展有关。在这篇综述中，我们描述了选择性剪接调控对主要信号转导途径的影响，并强调了选择性剪接的重要性。
