原发性阴道腺肉瘤伴肉瘤过度生长。
Primary vaginal adenosarcoma with sarcomatous overgrowth.
作者信息
Toyoshima Masafumi, Akahira Jun-ichi, Moriya Takuya, Hayakawa Seiichirou, Yaegashi Nobuo
机构信息
Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba, Sendai 980-8574, Japan.
出版信息
Gynecol Oncol. 2004 Dec;95(3):759-61. doi: 10.1016/j.ygyno.2004.08.004.
BACKGROUND
Primary vaginal adenosarcomas are extremely rare, and typical adenosarcomas are of low malignancy. However, aggressive forms with sarcomatous overgrowth have been reported, those appear to have a poor prognosis.
CASE
A 52-year-old woman who had undergone prior surgery for uterine leiomyoma and an ovarian cyst (total abdominal hysterectomy and left salpingo-oophorectomy) presented 10 years later with a rapidly enlarging tumor arising from the vaginal cuff. Repetitive biopsy samples revealed a mixture of benign epithelial gland and malignant stromal components with periglandular stromal hypercellularity and sarcomatous overgrowth. A histological diagnosis of mullerian adenocarcinoma was made. The patient died from recurrent disease 9 months after surgery.
CONCLUSION
Regardless of primary focus, adenosarcoma with sarcomatous overgrowth is associated with postoperative recurrence and a fatal outcome.
背景
原发性阴道腺肉瘤极为罕见，典型的腺肉瘤恶性程度较低。然而，已有报道称存在肉瘤过度生长的侵袭性形式，这些似乎预后不良。
病例
一名52岁女性，曾因子宫平滑肌瘤和卵巢囊肿接受过手术（全腹子宫切除术和左侧输卵管卵巢切除术），10年后出现阴道残端迅速增大的肿瘤。重复活检样本显示良性上皮腺体和恶性间质成分混合，伴有腺周间质细胞增多和肉瘤过度生长。做出了苗勒管腺癌的组织学诊断。患者术后9个月死于复发性疾病。
结论
无论原发部位如何，伴有肉瘤过度生长的腺肉瘤都与术后复发和致命结局相关。
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