Giannopoulos Theodoros, Butler-Manuel Simon, Tailor Anil
Department of Gynaecological Oncology, Royal Surrey County Hospital, Guildford, UK.
Gynecol Oncol. 2004 Dec;95(3):762-4. doi: 10.1016/j.ygyno.2004.09.010.
Primary treatment of endometrial cancer with progestogens is reserved for adjuvant or palliative treatment, although with unproven efficacy.
We present a case of early endometrial cancer where a combination of oral progestogens and levonorgestrel releasing intrauterine system (Mirena) was used as a primary treatment, as the standard surgical treatment was deemed to carry an unacceptable mortality risk.
Our treatment has resulted in reversion of the cancerous endometrial histological changes. This is encouraging, but obviously more cases and lengthier follow-up time are required in order to obtain more valid conclusions.
孕激素用于子宫内膜癌的初始治疗主要是辅助或姑息治疗，尽管其疗效尚未得到证实。
我们报告一例早期子宫内膜癌病例，由于标准手术治疗被认为具有不可接受的死亡风险，因此采用口服孕激素与左炔诺孕酮宫内缓释系统（曼月乐）联合作为初始治疗。
我们的治疗已使癌性子宫内膜的组织学变化发生逆转。这令人鼓舞，但显然需要更多病例和更长的随访时间才能得出更有效的结论。
