寻常型银屑病患者中LL-37、人β-防御素-2及CCR6 mRNA的表达
Expression of LL-37, human beta defensin-2, and CCR6 mRNA in patients with psoriasis vulgaris.
作者信息
Li Dongsheng, Li Jiawen, Duan Yiqun, Zhou Xiaoyong
机构信息
Department of Dermatology, the First Hospital of Wuhan, Wuhan 430022, China.
出版信息
J Huazhong Univ Sci Technolog Med Sci. 2004;24(4):404-6. doi: 10.1007/BF02861879.
To investigate whether LL-37 and human beta defensin-2 (hBD-2) is related to the patients with psoriasis seldom having skin infections and explore the role of the two peptides and CCR6 (the receptor of hBD-2) in the pathogenesis of psoriasis, the expression levels of mRNA of LL-37, hBD-2, and CCR6 in skin lesions of patients with psoriasis vulgaris were detected by using RT-PCR. The results showed that the mRNA expression levels of the two peptides and CCR6 in psoriatic lesions all increased compared with the normal skin (P<0.001). It was suggested that up-regulated expression of LL-37 and hBD-2 might be the main reason that result in the the skin of patients with psoriasis being seldom infected, and the two peptides and CCR6 might play crucial roles in the pathogenesis of psoriasis.
为研究LL-37和人β-防御素-2（hBD-2）是否与银屑病患者很少发生皮肤感染有关，并探讨这两种肽及CCR6（hBD-2的受体）在银屑病发病机制中的作用，采用逆转录聚合酶链反应（RT-PCR）检测寻常型银屑病患者皮损中LL-37、hBD-2及CCR6的mRNA表达水平。结果显示，与正常皮肤相比，银屑病皮损中这两种肽及CCR6的mRNA表达水平均升高（P<0.001）。提示LL-37和hBD-2表达上调可能是银屑病患者皮肤很少感染的主要原因，且这两种肽及CCR6可能在银屑病发病机制中起关键作用。
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